Description

Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing next-generation small molecule inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Biochemical Probe Development: Serves as a precursor for creating tool compounds to study specific enzymatic pathways and biological targets.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of proprietary Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Product Name	Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	1253791-05-7
Molecular Formula	C16H15N3O4S
Molecular Weight	345.37 g/mol
Synonyms	Ethyl 5-hydroxy-2-(methylthio)-7-oxo-8-(prop-2-yn-1-yl)-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 8-Propargyl-5-hydroxy-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; 1253791-05-7; Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative; Advanced kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, making this material suitable for advanced research and pre-clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.