Description

D-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is a protected derivative of the amino acid D-Tyrosine, featuring Fmoc (9-fluorenylmethoxycarbonyl) and tert-butyl ester protecting groups. This compound is critically important as a high-purity building block for solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of the D-enantiomer of tyrosine into complex peptide sequences. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including those targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Probe Development: Used to introduce the tyrosine moiety, a common site for labeling (e.g., with radioiodine or fluorescent tags), into biomolecules for diagnostic and imaging applications.
• Enzyme Substrate and Inhibitor Design: Employed in creating specific substrates or inhibitors for tyrosine kinases, phosphatases, and other enzymes.
• Production of Non-Natural and D-Amino Acid Peptides: Essential for constructing peptides with enhanced stability and novel biological properties by incorporating the D-enantiomer of tyrosine.
• Academic and Industrial Research: Serves as a fundamental reagent in biochemistry and medicinal chemistry laboratories for exploring protein structure-function relationships.

Basic Information

Item	Details
Product Name	D-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester
CAS No.	1253184-83-6
Molecular Formula	C28H29NO5
Molecular Weight	459.54 g/mol
Synonyms	Fmoc-D-Tyr(OtBu)-OH; Fmoc-D-Tyrosine(OtBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-tyrosine 1,1-dimethylethyl ester; N-Fmoc-D-tyrosine tert-butyl ester; Fmoc-D-Tyrosine(tBu)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxy)carbonyl)oxy)phenyl)propanoic acid; D-Tyrosine, N-Fmoc-O-t-butyl
EINECS	Contact for details

Quality Control

Our D-Tyrosine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to in-house specifications aligned with industry standards for peptide synthesis building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.