Description

n-Boc-5-Benzyloxy-2-Fluoroaniline is a protected aniline derivative featuring both tert-butoxycarbonyl (Boc) and benzyloxy protecting groups on a fluorinated aromatic ring. This compound is a critical pharmaceutical intermediate and building block in organic synthesis, valued for its role in constructing complex molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated aromatic amines.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity.
• Organic Synthesis Reagent: Serves as a versatile precursor for coupling reactions, such as Buchwald-Hartwig amination or Suzuki cross-coupling, after deprotection.
• Material Science Research: Employed in the development of novel organic electronic materials, dyes, and pigments.
• Peptide Mimetics & Conjugation: Useful for introducing fluorinated aniline motifs into peptide backbones or for bioconjugation strategies in drug discovery.
• Chemical Biology Probes: Acts as a starting material for creating fluorescent tags or molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	n-Boc-5-Benzyloxy-2-Fluoroaniline
CAS No.	1251033-10-9
Molecular Formula	C18H20FNO3
Molecular Weight	317.36 g/mol
Synonyms	5-(Benzyloxy)-2-fluoroaniline, N-Boc derivative; 2-Fluoro-5-(phenylmethoxy)aniline, 1,1-dimethylethyl carbamate; tert-Butyl [5-(benzyloxy)-2-fluorophenyl]carbamate; N-(tert-Butoxycarbonyl)-5-benzyloxy-2-fluoroaniline; Boc-5-BnO-2-F-aniline; 1,1-Dimethylethyl N-[5-(phenylmethoxy)-2-fluorophenyl]carbamate
EINECS	Contact for details

Quality Control

Our n-Boc-5-Benzyloxy-2-Fluoroaniline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.