Description

Benzyl 4-Chloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for the research and development of novel therapeutic agents, particularly as a key building block in kinase inhibitor synthesis. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in vitro to study specific biological pathways and enzyme inhibition mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	Benzyl 4-Chloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate
CAS No.	1251001-37-2
Molecular Formula	C17H16ClN3O2
Molecular Weight	329.78 g/mol
Synonyms	Benzyl 4-chloro-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-7-carboxylate; 7-Benzyloxycarbonyl-4-chloro-5,6,8,9-tetrahydropyrimido[4,5-d]azepine; 4-Chloro-5,6,8,9-tetrahydropyrimido[4,5-d]azepine-7-carboxylic acid benzyl ester; CAS 1251001-37-2; Pyrimidoazepine derivative; Kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Benzyl 4-Chloro-5,6,8,9-Tetrahydropyrimido[4,5-D]Azepine-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed in a dry, inert atmosphere to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.