Description

1-(3,5-Difluorophenyl)Cyclopropanemethanamine is a high-value, fluorinated cyclopropylamine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluorophenyl ring and a strained cyclopropane moiety, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms and cyclopropane ring can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the amine functionality for metal coordination.
• Material Science Research: Employed in the synthesis of specialty polymers or advanced organic materials where fluorinated aromatic components are required.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and tags to study biological systems and pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(3,5-Difluorophenyl)Cyclopropanemethanamine
CAS No.	1249615-63-1
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	1-(3,5-Difluorophenyl)cyclopropanemethanamine; 1-(3,5-Difluorophenyl)cyclopropylmethanamine; (1-(3,5-Difluorophenyl)cyclopropyl)methanamine; 3,5-Difluoro-α-(aminomethyl)cyclopropanebenzene; Cyclopropanemethanamine, 1-(3,5-difluorophenyl)-; α-(Aminomethyl)-3,5-difluorocyclopropanebenzene
EINECS	Contact for details

Quality Control

Our production of 1-(3,5-Difluorophenyl)Cyclopropanemethanamine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ISO 9001 quality management standards and can provide material suitable for use under GMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.