Description

3,5-Difluoro-4-(Tetrahydro-2H-Pyran-4-Yloxy)Benzenamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzenamine core substituted with fluorine and a tetrahydropyranyloxy group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its aromatic amine functionality.
• Fluorinated Compound Libraries: An essential component for combinatorial chemistry and high-throughput screening to discover new bioactive molecules.
• Academic & Industrial R&D: Used in chemical research for studying structure-activity relationships (SAR) and reaction mechanisms involving fluorinated anilines.

Basic Information

Product Name	3,5-Difluoro-4-(Tetrahydro-2H-Pyran-4-Yloxy)Benzenamine
CAS No.	1248914-51-3
Molecular Formula	C11H13F2NO2
Molecular Weight	229.22 g/mol
Synonyms	4-(3,5-Difluoro-4-aminophenoxy)tetrahydro-2H-pyran; 3,5-Difluoro-4-[(tetrahydro-2H-pyran-4-yl)oxy]aniline; 3,5-Difluoro-4-(tetrahydropyran-4-yloxy)aniline; 4-Amino-2,6-difluorophenyl tetrahydro-2H-pyran-4-yl ether; Benzenamine, 3,5-difluoro-4-(tetrahydro-2H-pyran-4-yloxy)-; 1248914-51-3; THP-protected difluoroaniline derivative
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Tetrahydro-2H-Pyran-4-Yloxy)Benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR, NMR), and impurity profiles are available for every lot. We adhere to cGMP principles where applicable to support our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for prolonged procedures to minimize oxidation risk. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.