Description

4-Cyclobutoxy-3,5-Difluorobenzenamine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated aniline structure with a cyclobutoxy substituent. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with enhanced bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the fluorine atoms for improved lipophilicity and environmental stability.
• Material Science: Serves as a monomer or precursor for specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Buchwald-Hartwig amination) to introduce the aniline moiety into complex molecular architectures.
• Ligand & Catalyst Development: Acts as a precursor for creating novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Cyclobutoxy-3,5-Difluorobenzenamine
CAS No.	1248130-27-9
Molecular Formula	C10H11F2NO
Molecular Weight	199.20 g/mol
Synonyms	3,5-Difluoro-4-cyclobutoxyaniline; 4-Amino-2,6-difluorophenyl cyclobutyl ether; Benzenamine, 4-cyclobutoxy-3,5-difluoro-; 2,6-Difluoro-4-cyclobutoxyaniline; 4-(Cyclobutoxy)-3,5-difluoroaniline; 3,5-Difluoro-4-(cyclobutyloxy)aniline; 1248130-27-9
EINECS	Contact for details

Quality Control

Our 4-Cyclobutoxy-3,5-Difluorobenzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.