Description

Fmoc-D-Methionine Sulfone is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the sulfone-modified methionine residue with D-configuration, enabling precise control over peptide structure and bioactivity. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and the production of complex therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used to incorporate D-methionine sulfone residues into peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Proteomics Research: Used in the study of protein structure-function relationships and the design of enzyme inhibitors or receptor ligands.
• Peptidomimetic Development: Enables the creation of metabolically stable peptide analogs with enhanced therapeutic properties.
• Bioconjugation: Can be utilized for site-specific labeling or functionalization of peptides and proteins.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive molecules.

Basic Information

Product Name	Fmoc-D-Methionine Sulfone
CAS No.	1247791-23-6
Molecular Formula	C₂₁H₂₃NO₆S
Molecular Weight	417.47 g/mol
Synonyms	Fmoc-D-Met(O₂)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-methionine sulfone; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfonyl)butanoic acid; Fmoc-D-methionine S,S-dioxide; Fmoc-D-Met(O2)-OH; N-Fmoc-D-methionine sulfone; D-Methionine sulfone, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-D-Methionine Sulfone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.