Description

2-Chloro-5-Methylpyrimidin-4-Ol CAS NO 1246763-80-3 is a versatile pyrimidine derivative, a crucial heterocyclic building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used as a building block for developing new herbicides, fungicides, and plant growth regulators.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies.
• Material Science: Potential intermediate in the synthesis of organic electronic materials and ligands for metal-organic frameworks (MOFs).
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical production.

Basic Information

Product Name	2-Chloro-5-Methylpyrimidin-4-Ol
CAS No.	1246763-80-3
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	4-Hydroxy-2-chloro-5-methylpyrimidine; 2-Chloro-5-methyl-4-pyrimidinol; 2-Chloro-5-methyl-4(1H)-pyrimidinone; 5-Methyl-2-chloropyrimidin-4-ol; 2-Chloro-5-methyl-4-hydroxypyrimidine; 4(1H)-Pyrimidinone, 2-chloro-5-methyl-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methylpyrimidin-4-Ol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.