Description

1-Amino-3-Hydroxycyclobutanecarboxylic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative featuring a constrained cyclobutane ring system. This compound is a critical pharmaceutical intermediate and building block for advanced medicinal chemistry research, particularly in the development of novel peptide-based therapeutics and enzyme inhibitors. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors seeking to incorporate rigid, functionalized amino acid motifs into their molecular designs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide mimetics.
• Peptidomimetic Research: Used to introduce conformational constraints into peptide backbones to enhance metabolic stability, potency, and selectivity.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of specific enzymes like proteases, which are targets in various disease pathways.
• Chemical Biology & Probe Synthesis: Employed in the creation of molecular probes to study enzyme function and protein-protein interactions.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists exploring new methodologies and compound libraries.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	1-Amino-3-Hydroxycyclobutanecarboxylic Acid Hydrochloride
CAS No.	1246746-62-2
Molecular Formula	C5H10ClNO3
Molecular Weight	167.59 g/mol
Synonyms	(1R,3S)-1-Amino-3-hydroxycyclobutane-1-carboxylic acid hydrochloride; (1S,3R)-1-Amino-3-hydroxycyclobutane-1-carboxylic acid hydrochloride; 1-Amino-3-hydroxycyclobutanecarboxylic acid HCl; 3-Hydroxy-1-aminocyclobutanecarboxylic acid hydrochloride; trans-1-Amino-3-hydroxycyclobutanecarboxylic acid hydrochloride; Cyclobutane amino acid derivative; AHCBC-HCl
EINECS	Contact for details

Quality Control

Our 1-Amino-3-Hydroxycyclobutanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.