Description

1-Cyclopropyl-6-Fluoro-8-Methoxy-4-Oxo-7-(Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride is a high-purity advanced pharmaceutical intermediate (API intermediate) with a complex heterocyclic structure. This compound is critical for the synthesis of novel quinolone-based antibacterial agents, offering a key building block for targeted drug development. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of next-generation antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold in the research and synthesis of new-generation fluoroquinolone antibiotics.
• Antibacterial Drug Development: Used in preclinical and clinical-stage research for developing compounds targeting resistant bacterial strains.
• Medicinal Chemistry Research: A valuable reagent for structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, biologically active molecules.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for GMP-scale API production.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Item	Detail
Product Name	1-Cyclopropyl-6-Fluoro-8-Methoxy-4-Oxo-7-(Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride
CAS No.	1246654-75-0
Molecular Formula	C22H23FN3O4 • HCl
Molecular Weight	449.90 g/mol (Free base: 412.44 g/mol)
Synonyms	1-Cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(tetrahydro-1H-pyrrolo[3,4-b]pyridin-6(2H,7H,7aH)-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; 1-Cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; Quinolone carboxylic acid derivative hydrochloride; Antibacterial intermediate 1246654-75-0; 7-(Octahydropyrrolo[3,4-b]pyridin-6-yl) fluoroquinolone intermediate HCl salt.
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-6-Fluoro-8-Methoxy-4-Oxo-7-(Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with batch-specific data are available upon request. We support compliance with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to prevent degradation from moisture and light exposure. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.