Description

(S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, enabling the precise construction of complex peptide sequences with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected glutamic acid derivative with a tert-butyl ester side chain, it is a key intermediate for the controlled incorporation of glutamic acid residues.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Facilitates the creation of modified peptide structures with enhanced stability, bioavailability, or receptor binding affinity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation: The carboxylic acid moiety allows for further functionalization and conjugation to other molecules or surfaces.
• Academic Research: A valuable reagent for studies in biochemistry, medicinal chemistry, and chemical biology focusing on peptide structure and function.

Basic Information

Item	Detail
Product Name	(S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid
CAS No.	1246651-90-0
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-Glu(OtBu)-OH; N-α-Fmoc-L-glutamic acid 5-tert-butyl ester; Fmoc-L-Glu(OtBu)-OH; (S)-5-(tert-Butoxy)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-oxopentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamic acid 1-tert-butyl ester; Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester); Fmoc-L-glutamic acid α-tert-butyl ester; Fmoc-Glu(OtBu)
EINECS	Contact for details

Quality Control

Our (S)-3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-5-(tert-Butoxy)-5-Oxopentanoic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and provide full traceability documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon or nitrogen) after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.