Description

Tau Peptide (379-408) is a synthetic peptide fragment corresponding to amino acid residues 379-408 of the human microtubule-associated protein tau. This high-purity peptide is a critical research tool for studying tau protein function, aggregation mechanisms, and related neurodegenerative pathologies. It is essential for researchers and developers in the fields of neuroscience, biochemistry, and pharmaceutical discovery, particularly for those investigating Alzheimer's disease and other tauopathies.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic assays to study tau phosphorylation, cleavage, and aggregation kinetics.
• Neuroscience Studies: Critical for in vitro and cellular models investigating the role of specific tau domains in neurofibrillary tangle formation and neuronal toxicity.
• Antibody Development & Validation: Serves as a key antigen for the production and specificity testing of antibodies targeting the tau protein.
• Drug Discovery Screening: Employed in high-throughput screening assays to identify potential therapeutic compounds that inhibit abnormal tau aggregation or promote clearance.
• Diagnostic Assay Development: Used in the development and calibration of immunoassays (e.g., ELISA) for detecting tau biomarkers in biological fluids.
• Structural Biology: Provides material for NMR, X-ray crystallography, and other techniques to elucidate the structure-function relationship of the tau protein.

Basic Information

Product Name	Tau Peptide (379-408)
CAS No.	1246357-53-8
Molecular Formula	C150H238N44O48S
Molecular Weight	~3393.8 g/mol
Synonyms	Tau (379-408) peptide; Human tau protein fragment 379-408; Microtubule-associated protein tau (379-408); Tau peptide fragment; pTau peptide (379-408); Alzheimer's disease tau peptide; Neurofibrillary tangle-related peptide; MAPT (379-408)
EINECS	Contact for details

Quality Control

Our Tau Peptide (379-408) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including mass spectrometry (MS) for sequence confirmation and purity assessment by reverse-phase HPLC. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical composition
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.