Description

Fmoc-(Rs)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid is a non-natural, sterically hindered amino acid derivative featuring an Fmoc-protected amino group and a tertiary β-hydroxy group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, where it introduces structural rigidity and unique hydrogen-bonding capabilities. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is directly used in automated peptide synthesizers for the controlled incorporation of a constrained, hydroxy-functionalized residue into peptide chains.
• Peptidomimetic Drug Discovery: Serves as a key scaffold for creating peptide analogs with enhanced metabolic stability, improved bioavailability, and specific target affinity by mimicking natural peptide secondary structures.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Libraries for High-Throughput Screening (HTS): Incorporated into combinatorial peptide libraries to discover new lead compounds with therapeutic potential against various diseases.
• Material Science & Bioconjugation: The reactive carboxylic acid and hydroxy groups enable its use in creating functionalized surfaces, polymers, or carrier systems for targeted delivery applications.

Basic Information

Product Name	Fmoc-(Rs)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid
CAS No.	1246172-30-4
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	Fmoc-(R,S)-2-Amino-3-hydroxy-3-methylbutyric acid; Fmoc-β-Hydroxy-tert-leucine; Fmoc-Hot-OH; N-(9-Fluorenylmethoxycarbonyl)-3-hydroxy-3-methyl-DL-norvaline; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxy-3-methylbutanoic acid; Fmoc-DL-β-Hydroxy-tert-leucine; Fmoc-3-Hydroxy-3-methyl-DL-norvaline; Nα-Fmoc-β-hydroxy-tert-leucine
EINECS	Contact for details

Quality Control

Our Fmoc-(Rs)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Specified enantiomeric ratio (Rs) provided
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.