Description

5-Pyrimidinepropanoic Acid, 1,6-Dihydro-4-Hydroxy-β-Methyl-6-Oxo-, Methyl Ester, (βr)- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized pyrimidine core. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, particularly in modern medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including potential antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Medicinal Chemistry Research: Used as a scaffold or precursor in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Antiviral Drug Development: Potential building block for the research and synthesis of nucleotide/nucleoside analog prodrugs targeting viral polymerases.
• Oncology Research: Employed in the development of small-molecule inhibitors targeting specific enzymes or pathways involved in cancer cell proliferation.
• Process Chemistry & Scale-Up: Used in route scouting and process development for the efficient, scalable production of candidate drugs.
• Bioconjugation & Prodrug Synthesis: The ester and acid functionalities allow for further chemical modifications to create prodrugs or conjugate with targeting moieties.

Basic Information

Product Name	5-Pyrimidinepropanoic Acid, 1,6-Dihydro-4-Hydroxy-β-Methyl-6-Oxo-, Methyl Ester, (βr)-
CAS No.	1245646-90-5
Molecular Formula	C9H12N2O4
Molecular Weight	212.20 g/mol
Synonyms	(βr)-Methyl 1,6-dihydro-4-hydroxy-β-methyl-6-oxo-5-pyrimidinepropanoate; (R)-Methyl 3-(1,6-dihydro-4-hydroxy-2-methyl-6-oxopyrimidin-5-yl)propanoate; 5-Pyrimidinepropanoic acid, 1,6-dihydro-4-hydroxy-β-methyl-6-oxo-, methyl ester, (R)-; (R)-1,6-Dihydro-4-hydroxy-β-methyl-6-oxo-5-pyrimidinepropanoic acid methyl ester; A key intermediate for GS-441524; Remdesivir intermediate derivative; β-Methyl-substituted dihydropyrimidine ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) documenting all release specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.