Description

2-Pyrimidinamine, 4-Chloro-5-Methyl-n-[3-(4-Methyl-1-Piperazinyl)Phenyl]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapy research. Pharmaceutical manufacturers and advanced R&D laboratories need this material for developing next-generation therapeutic agents, where precise molecular architecture is paramount for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of targeted cancer therapies and other specialized small-molecule drugs.
• Oncology Drug Discovery: Used as a core scaffold in medicinal chemistry programs focused on kinase inhibitors and other oncology targets.
• Chemical Biology Research: Employed as a probe or ligand in biochemical assays to study protein-ligand interactions and signaling pathways.
• Process Development & Scale-Up: Supplied to CROs and CDMOs for route scouting, optimization, and pilot-scale production of candidate drugs.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis Building Block: Provides a versatile starting point for the custom synthesis of novel chemical entities for client-specific research programs.

Basic Information

Product Name	2-Pyrimidinamine, 4-Chloro-5-Methyl-n-[3-(4-Methyl-1-Piperazinyl)Phenyl]-
CAS No.	1245646-20-1
Molecular Formula	C16H21ClN6
Molecular Weight	332.83 g/mol
Synonyms	4-Chloro-5-methyl-N-[3-(4-methylpiperazin-1-yl)phenyl]pyrimidin-2-amine; 4-Chloro-5-methyl-N-(3-(4-methyl-1-piperazinyl)phenyl)-2-pyrimidinamine; 1245646-20-1; UNII-9H0G1CJ4Q5; 9H0G1CJ4Q5; 2-Pyrimidinamine, 4-chloro-5-methyl-N-[3-(4-methyl-1-piperazinyl)phenyl]-; AKOS025310947; BDBM50388825
EINECS	Contact for details

Quality Control

Our 2-Pyrimidinamine, 4-Chloro-5-Methyl-n-[3-(4-Methyl-1-Piperazinyl)Phenyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.