Description

2-[[6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities (NCEs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates and investigational new drugs.
• API Synthesis: Serves as a core scaffold for constructing complex molecules with potential biological activity in medicinal chemistry programs.
• Research & Development: Used in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new therapeutic agents.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Investigated for its potential interactions with biological targets in biochemical assays.
• Custom Synthesis: A starting material for contract manufacturing and custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-[[6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxylic Acid
CAS No.	1245157-42-9
Molecular Formula	C15H21N7O3S
Molecular Weight	379.44 g/mol
Synonyms	5-Thiazolecarboxylic acid, 2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-; 2-((6-(4-(2-Hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid; UNII-8J3Z5M6N4P; 8J3Z5M6N4P; 2-({6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.