Description

2-Methoxy-5-(Pyrimidin-4-Yl)Benzoic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture combining benzoic acid and pyrimidine motifs. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapies. It is primarily required by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers engaged in the development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially kinase inhibitors.
• Oncology Research: Serves as a core scaffold for developing targeted cancer therapies due to the pyrimidine moiety's prevalence in many anticancer agents.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• API Development: Integral to the synthetic route of complex active pharmaceutical ingredients requiring a specific methoxy-pyrimidinyl-benzoic acid subunit.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material and commercial API production.
• Biochemical Research: Potential use as a reference standard or probe in biochemical assays studying enzyme inhibition.

Basic Information

Product Name	2-Methoxy-5-(Pyrimidin-4-Yl)Benzoic Acid
CAS No.	1244949-12-9
Molecular Formula	C₁₂H₁₀N₂O₃
Molecular Weight	230.22 g/mol
Synonyms	4-(6-Methoxy-3-pyrimidinyl)benzoic acid; 5-(Pyrimidin-4-yl)-2-methoxybenzoic acid; 2-Methoxy-5-(4-pyrimidinyl)benzoic acid; Benzoic acid, 2-methoxy-5-(4-pyrimidinyl)-; 1244949-12-9; 2-Methoxy-5-(pyrimidin-4-yl)benzoic acid
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Pyrimidin-4-Yl)Benzoic Acid is manufactured under strict quality management systems. We offer material suitable for research and cGMP-grade synthesis, with typical purity levels exceeding 97% (HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality commitment ensures consistency and reliability for critical pharmaceutical development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.