Description

(2S,4S)-Fmoc-4-Trifluoromethyl-Pyrrolidine-2-Carboxylic Acid CAS NO 1242934-32-2 is a high-purity, non-natural amino acid derivative featuring a stereochemically defined pyrrolidine scaffold and a trifluoromethyl group. This compound is a critical building block for the synthesis of complex peptides and peptidomimetics, where it introduces conformational constraints and enhances metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, including protease inhibitors and targeted biologics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid for the automated synthesis of therapeutic peptides.
• Peptidomimetic Drug Discovery: Used to incorporate a rigid, trifluoromethyl-substituted pyrrolidine ring into drug candidates to improve binding affinity and pharmacokinetic properties.
• Protease Inhibitor Development: A valuable precursor for creating inhibitors targeting enzymes like HCV NS3/4A protease or DPP-4.
• Chemical Biology & Probe Design: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme function and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: Used to generate focused chemical libraries featuring fluorinated and conformationally restricted motifs.
• Academic & Industrial Research: A fundamental reagent for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	(2S,4S)-Fmoc-4-Trifluoromethyl-Pyrrolidine-2-Carboxylic Acid
CAS No.	1242934-32-2
Molecular Formula	C22H20F3NO4
Molecular Weight	419.40 g/mol
Synonyms	Fmoc-(2S,4S)-4-(Trifluoromethyl)pyrrolidine-2-carboxylic acid; (2S,4S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(trifluoromethyl)pyrrolidine-2-carboxylic acid; (2S,4S)-1-Fmoc-4-(trifluoromethyl)pyrrolidine-2-carboxylic acid; Fmoc-TfmPro-OH; Fmoc-4-CF3-Pro-OH (stereospecific); N-α-Fmoc-4-trifluoromethyl-L-proline; (S,S)-Fmoc-4-Trifluoromethylproline
EINECS	Contact for details

Quality Control

Our (2S,4S)-Fmoc-4-Trifluoromethyl-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.