Description

4-(4-Aminosulfonylphenoxy)-6-Chloropyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine core functionalized with chlorophenyl and aminosulfonylphenoxy groups. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D and fine chemical synthesis professionals need it for developing new drug candidates, especially in oncology and antiviral research, where precise molecular modification is paramount.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic structure for bioactivity.
• Organic Synthesis Reagent: Serves as a versatile precursor for constructing more complex molecules via Suzuki coupling, nucleophilic aromatic substitution, and other cross-coupling reactions.
• Material Science: Potential monomer or additive in the research of specialty polymers and advanced organic electronic materials.
• Bioconjugation Chemistry: The reactive chloropyrimidine moiety can be utilized for labeling biomolecules in diagnostic assay development.

Basic Information

Product Name	4-(4-Aminosulfonylphenoxy)-6-Chloropyrimidine
CAS No.	1242240-93-2
Molecular Formula	C10H8ClN3O3S
Molecular Weight	285.71 g/mol
Synonyms	6-Chloro-4-[(4-sulfamoylphenoxy)]pyrimidine; 4-(4-Sulfamoylphenoxy)-6-chloropyrimidine; 4-(6-Chloropyrimidin-4-yloxy)benzenesulfonamide; 6-Chloro-4-(4-sulfamoylphenoxy)pyrimidine; 4-(4-Aminosulfonylphenoxy)-6-chloro-pyrimidine; 1242240-93-2; 4-(6-Chloro-4-pyrimidinyloxy)benzenesulfonamide
EINECS	Contact for details

Quality Control

Our 4-(4-Aminosulfonylphenoxy)-6-Chloropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.