Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, 2-Oxo-2-(1-Pyrrolidinyl)Ethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated building block with a defined stereochemical and functional group profile. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing next-generation antibacterial and antimicrobial agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the production of novel fluoroquinolone-class antibacterial agents.
• Antimicrobial Research: Serves as a core scaffold for the development of new compounds targeting DNA gyrase and topoisomerase IV enzymes.
• Process Chemistry: Used in scale-up and optimization studies for API manufacturing routes in GMP environments.
• Medicinal Chemistry R&D: A valuable building block for structure-activity relationship (SAR) studies to enhance potency and reduce bacterial resistance.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API production.
• Custom Synthesis: Basis for the custom synthesis of proprietary derivatives and analogs for preclinical evaluation.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-, 2-Oxo-2-(1-Pyrrolidinyl)Ethyl Ester
CAS No.	1241966-80-2
Molecular Formula	C25H30FN5O5
Molecular Weight	499.54 g/mol
Synonyms	1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 2-oxo-2-(pyrrolidin-1-yl)ethyl ester; (1-Cyclopropyl-6-fluoro-7-(4-ethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carbonyloxy)acetic acid pyrrolidide; Garenoxacin Prodrug Ester; Garenoxacin intermediate ester derivative; Prodrug of Garenoxacin; DW-224a derivative; T-3811ME intermediate; Quinolone antibacterial intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems, ensuring batch-to-batch consistency and traceability. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, residual solvent analysis, and control of specified impurities. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements. We support development and commercial projects with material suitable for use under GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.