Description

Apelin-36 (1-16) Amide (Human) is a bioactive peptide fragment derived from the endogenous apelin system, a key regulator in cardiovascular function and fluid homeostasis. This high-purity synthetic peptide is critical for advanced research into the apelin receptor (APJ) signaling pathway and its therapeutic potential. It is an essential reagent for pharmaceutical R&D, academic research, and diagnostic development focusing on cardiovascular diseases, metabolic disorders, and related physiological processes.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the apelin/APJ system, investigating its role in vasodilation, angiogenesis, and heart function.
• Drug Discovery & Development: Serves as a key pharmacophore and lead compound for developing novel therapeutics targeting hypertension, heart failure, and diabetes.
• In Vitro & In Vivo Assays: Essential for functional cell-based assays (e.g., cAMP accumulation, receptor binding) and animal model studies to validate biological activity.
• Diagnostic Kit Development: Utilized as a calibrator or component in the development of immunoassays (ELISA, RIA) for detecting apelin levels in biological samples.
• Signal Transduction Studies: Applied in research to elucidate downstream signaling mechanisms of G-protein coupled receptors (GPCRs).
• Peptide Chemistry & Conjugation: Acts as a starting material for creating labeled derivatives (e.g., fluorescent, biotinylated) for imaging and detection applications.

Basic Information

Product Name	Apelin-36 (1-16) Amide (Human)
CAS No.	1241836-78-1
Molecular Formula	C81H134N26O22S
Molecular Weight	1839.1 g/mol
Synonyms	Apelin-36 (1-16) Amide; Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-Trp-Ala-Pro-Arg-NH2; Apelin 36 (1-16) amide, human; Apelin-36 (1-16)-NH2; [Pyr1]-Apelin-36 (1-16) Amide; APJ Receptor Ligand (1-16) Amide; UNII-9J6K9N8Z4M
EINECS	Contact for details

Quality Control

Our Apelin-36 (1-16) Amide (Human) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and content. We adhere to GMP principles for peptide synthesis, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, or acetic acid solution

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.