Description

3,5-Dihydroxy-D-Phenylalanine is a specialized, non-natural derivative of the amino acid L-DOPA, distinguished by its unique substitution pattern. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of novel drug candidates, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder therapeutics.
• Biochemical Research: Used as a substrate or precursor in enzymatic studies and metabolic pathway investigations due to its structural similarity to natural catecholamines.
• Asymmetric Synthesis: Employed as a chiral pool starting material or auxiliary in the synthesis of complex, enantiomerically pure molecules for medicinal chemistry.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Peptide Modification: Can be incorporated into synthetic peptides to introduce catechol functionality, altering bioactivity and physicochemical properties.

Basic Information

Product Name	3,5-Dihydroxy-D-Phenylalanine
CAS No.	1241680-13-6
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	D-3,5-Dihydroxyphenylalanine; (R)-2-Amino-3-(3,5-dihydroxyphenyl)propanoic acid; 3,5-DiOH-D-Phe; 3,5-Dihydroxy-DOPA; (R)-3,5-Dihydroxy-phenylalanine; 3,5-Dihydroxy-D-Phe-OH
EINECS	Contact for details

Quality Control

Every batch of 3,5-Dihydroxy-D-Phenylalanine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade typically meets high-purity research specifications, with testing including HPLC for assay and chiral purity, and IR for identification. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific pharmacopeial (e.g., USP) or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.