Description

(S)-5,7-Difluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine is a high-purity, chiral amine building block of significant importance in modern pharmaceutical research and development. Its value lies in its unique fluorinated tetralin scaffold, which is strategically employed to modulate the potency, metabolic stability, and bioavailability of drug candidates. This compound is essential for medicinal chemists and process development scientists working on central nervous system (CNS) agents, enzyme inhibitors, and other therapeutic programs requiring sophisticated fluorinated intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in neuroscience and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore fluorination effects on drug-like properties such as lipophilicity and membrane permeability.
• Asymmetric Synthesis: Serves as a valuable chiral amine precursor or resolving agent in the preparation of enantiomerically pure compounds.
• Ligand and Catalyst Development: Potential building block for creating novel chiral ligands or organocatalysts used in asymmetric transformations.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological targets and pathways.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization towards the commercial manufacturing of advanced drug candidates.

Basic Information

Product Name	(S)-5,7-Difluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine
CAS No.	1241679-51-5
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	(1S)-5,7-Difluoro-1,2,3,4-tetrahydronaphthalen-1-amine; (S)-5,7-Difluoro-1,2,3,4-tetrahydro-1-naphthylamine; (S)-1-Amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene; 1-Tetralinamine, 5,7-difluoro-, (1S)-; (S)-5,7-Difluoro-1,2,3,4-tetrahydro-1-naphthalenamine; (S)-5,7-Difluoro-α-tetralinamine; (1S)-5,7-Difluoro-1,2,3,4-tetrahydro-1-naphthalenamine
EINECS	Contact for details

Quality Control

Our (S)-5,7-Difluoro-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.