Description

2-(Chloromethyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one is a high-value pyrimidine derivative and a versatile chemical building block. Its molecular structure, featuring both a reactive chloromethyl group and a stable trifluoromethyl substituent, makes it a critical intermediate for synthesizing advanced compounds. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a crucial precursor for creating next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Used in the synthesis of specialized polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(Chloromethyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one
CAS No.	1240596-45-5
Molecular Formula	C6H4ClF3N2O
Molecular Weight	212.56 g/mol
Synonyms	4(3H)-Pyrimidinone, 2-(chloromethyl)-6-(trifluoromethyl)-; 2-(Chloromethyl)-6-(trifluoromethyl)-4-pyrimidinol; 6-(Trifluoromethyl)-2-(chloromethyl)pyrimidin-4-ol; 2-(Chloromethyl)-6-(trifluoromethyl)pyrimidin-4-ol; 4-Hydroxy-2-(chloromethyl)-6-(trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and we can support custom specifications for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.