Description

tert-Butyl ((5-Chloropyrimidin-2-yl)methyl)carbamate is a high-purity, protected amine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs) and agrochemicals, where the tert-butoxycarbonyl (Boc) protecting group and chloropyrimidine moiety offer strategic handles for further functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, leveraging the bioactive pyrimidine core.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes to study biological pathways.
• Peptidomimetics & Conjugate Chemistry: The protected amine functionality is valuable for constructing peptide-like structures or bioconjugates.
• Material Science: Potential monomer or linker in the synthesis of specialized polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity intermediates.

Basic Information

Product Name	tert-Butyl ((5-Chloropyrimidin-2-yl)methyl)carbamate
CAS No.	1240594-60-8
Molecular Formula	C10H14ClN3O2
Molecular Weight	243.69 g/mol
Synonyms	Boc-5-chloro-2-pyrimidinylmethylamine; N-(tert-Butoxycarbonyl)-5-chloro-2-pyrimidinemethanamine; tert-Butyl N-[(5-chloropyrimidin-2-yl)methyl]carbamate; 2-[[(tert-Butoxycarbonyl)amino]methyl]-5-chloropyrimidine; 5-Chloro-2-((Boc-amino)methyl)pyrimidine; (5-Chloro-pyrimidin-2-ylmethyl)-carbamic acid tert-butyl ester; Boc-Aminomethyl-5-chloropyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl ((5-Chloropyrimidin-2-yl)methyl)carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.