Description

tert-Butyl (4-Chloropyrimidin-2-Yl)Methylcarbamate CAS NO 1240594-10-8 is a high-purity, advanced pharmaceutical intermediate featuring a chloropyrimidine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing kinase inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology and antiviral drug candidates.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor for the design and synthesis of novel protein kinase inhibitors due to its pyrimidine structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to explore new chemical entities.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules under cGMP conditions.
• Bioconjugation & Probe Synthesis: The reactive chlorine atom and protected amine allow for further functionalization, useful in creating biochemical probes or antibody-drug conjugate (ADC) linkers.

Basic Information

Product Name	tert-Butyl (4-Chloropyrimidin-2-Yl)Methylcarbamate
CAS No.	1240594-10-8
Molecular Formula	C10H14ClN3O2
Molecular Weight	243.69 g/mol
Synonyms	Boc-4-Chloro-2-pyrimidinylmethylamine; tert-Butyl N-[(4-Chloropyrimidin-2-Yl)Methyl]Carbamate; 2-[(tert-Butoxycarbonyl)Amino]Methyl-4-Chloropyrimidine; 4-Chloro-2-((((2-Methyl-2-Propanyl)Oxy)Carbonyl)Amino)Methyl)Pyrimidine; (4-Chloro-Pyrimidin-2-Ylmethyl)-Carbamic Acid Tert-Butyl Ester; N-Boc-2-(Aminomethyl)-4-Chloropyrimidine; 1240594-10-8; tert-Butyl (4-Chloro-2-Pyrimidinylmethyl)Carbamate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl (4-Chloropyrimidin-2-Yl)Methylcarbamate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical R&D and cGMP synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles via validated methods such as HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.