Description

2-Methoxy-5-(Pentafluorosulfur)Benzylbromide is a high-value, multi-functional organofluorine building block characterized by its benzyl bromide and pentafluorosulfanyl (SF5) functional groups. This compound matters for its unique ability to introduce both a reactive benzylic halide handle and the highly stable, lipophilic SF5 moiety into target molecules, a combination sought after in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel chemical entities with enhanced metabolic stability and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders and inflammatory diseases, where the SF5 group can improve metabolic stability and membrane permeability.
• Agrochemical Research: Used in creating advanced herbicides, fungicides, and insecticides, leveraging the SF5 group's influence on biological activity and environmental persistence.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs) to enhance thermal stability and electronic properties.
• Polymer & Specialty Material Modifier: Incorporated into polymers and coatings to impart unique surface characteristics, chemical resistance, and durability.
• Cross-Coupling Reactions: The benzyl bromide moiety makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Radiolabeling Precursor: Potential use as a starting material for synthesizing fluorinated tracers for Positron Emission Tomography (PET) imaging agents.

Basic Information

Item	Details
Product Name	2-Methoxy-5-(Pentafluorosulfur)Benzylbromide
CAS No.	1240257-53-7
Molecular Formula	C9H8BrF5OS
Molecular Weight	323.12 g/mol
Synonyms	1-(Bromomethyl)-2-methoxy-5-(pentafluoro-λ6-sulfanyl)benzene; (2-Methoxy-5-(pentafluorosulfanyl)phenyl)methyl bromide; 5-(SF5)-2-Methoxybenzyl Bromide; α-Bromo-2-methoxy-5-(pentafluorosulfanyl)toluene; 2-Methoxy-5-pentafluorosulfanylbenzyl bromide; SF5-Benzyl Bromide Derivative
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Pentafluorosulfur)Benzylbromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere to minimize degradation and moisture uptake. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Standard Grade)
Purity (HPLC)	≥ 98% (High Purity Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.