Description

5-Bromo-4-hydrazinylthieno[2,3-d]pyrimidine CAS NO 1239460-84-4 is a high-purity heterocyclic building block featuring a reactive hydrazinyl group and a bromine substituent. This compound is a critical intermediate in modern pharmaceutical research and development, enabling the synthesis of novel drug candidates. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core scaffold in the design and synthesis of potent and selective kinase inhibitors due to its thienopyrimidine structure.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	5-Bromo-4-hydrazinylthieno[2,3-d]pyrimidine
CAS No.	1239460-84-4
Molecular Formula	C6H6BrN5S
Molecular Weight	244.12 g/mol
Synonyms	5-Bromo-4-hydrozinylthieno[2,3-d]pyrimidine; 4-Hydrazinyl-5-bromothieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidine, 5-bromo-4-hydrozinyl-; 5-Bromo-4-hydrazinyl-thieno[2,3-d]pyrimidine; 1239460-84-4; 5-Br-4-Hydrazinyl-TP; 5-Bromo-4-hydrozinylthienopyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-hydrazinylthieno[2,3-d]pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere to minimize oxidation. Keep the container sealed to protect this moisture-sensitive material from humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.