Description

(Des-Glu22)-Amyloid β-Protein (1-42) is a specific, modified peptide fragment of the amyloid-beta protein, a key molecule in neurological research. This compound is crucial for studying the molecular mechanisms of amyloid plaque formation and aggregation, which are central to understanding neurodegenerative conditions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers focused on Alzheimer's disease and related pathologies.

Application

• Biochemical Research: Fundamental studies on amyloid-beta peptide aggregation kinetics, structure, and toxicity.
• Drug Discovery & Screening: Serving as a target or reagent in high-throughput assays to identify potential therapeutic compounds that inhibit aggregation.
• Antibody & Assay Development: Used as an antigen for generating and characterizing specific antibodies in immunoassays and diagnostic test kits.
• Neuroscience Studies: In vitro and in vivo modeling of amyloid-related pathology to investigate disease mechanisms.
• Reference Standard: Acting as a well-defined control material in analytical methods like HPLC and mass spectrometry for quality control in related research.

Basic Information

Product Name	(Des-Glu22)-Amyloid β-Protein (1-42)
CAS No.	1239313-74-6
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol (approximately)
Synonyms	Aβ(1-42) (Des-Glu22); Amyloid β-Protein (1-42) (Des-Glu22); Des-Glu22-Aβ42; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Single-Letter: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA); (Des-E22)-Aβ42; Modified Amyloid-β (1-42) Peptide; Aβ42 E22del
EINECS	Contact for details

Quality Control

Our (Des-Glu22)-Amyloid β-Protein (1-42) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot is characterized by advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4514.0 ± 2.0 Da (MALDI-TOF MS)
Solubility	Soluble in dilute ammonia solution or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.