Description

3-(3-Fluorophenoxy)-Azetidine Hcl is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring system substituted with a fluorophenoxy moiety. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system and other therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those requiring a constrained azetidine scaffold for improved metabolic stability and receptor binding.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the fluorophenoxy-azetidine fragment on potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core structural component in the research of inhibitors for various protease enzymes.
• Ligand for Receptor Targeting: Employed in the design and synthesis of ligands for G-protein-coupled receptors (GPCRs) and other biological targets relevant to neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized to create tool compounds for investigating specific biological pathways and protein functions.
• Custom Synthesis: A starting material for contract manufacturing and custom synthesis services catering to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	3-(3-Fluorophenoxy)-Azetidine Hcl
CAS No.	1236861-75-8
Molecular Formula	C9H10FNO•HCl
Molecular Weight	203.64 g/mol (Free base: 167.18 g/mol)
Synonyms	3-(3-Fluorophenoxy)azetidine hydrochloride; Azetidine, 3-(3-fluorophenoxy)-, hydrochloride; 1-(3-Fluorophenoxy)-3-azetidine hydrochloride; 3-Fluorophenoxyazetidine HCl; 3-Azetidinyl 3-fluorophenyl ether hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Fluorophenoxy)-Azetidine Hcl is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request, supporting compliance with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.