Description

tert-Butyl 3-(pyrimidin-2-yl)azetidine-1-carboxylate is a high-purity, protected azetidine building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceuticals and agrochemicals, enabling the rapid construction of complex molecular architectures. It is primarily utilized by research and development teams in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine and azetidine pharmacophores.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.
• Academic and Institutional Research: Used in university and government laboratories for methodological development and exploratory chemistry.

Basic Information

Product Name	tert-Butyl 3-(Pyrimidin-2-Yl)Azetidine-1-Carboxylate
CAS No.	1236861-59-8
Molecular Formula	C12H17N3O2
Molecular Weight	235.29 g/mol
Synonyms	1-Boc-3-(2-pyrimidinyl)azetidine; 1-(tert-Butoxycarbonyl)-3-(pyrimidin-2-yl)azetidine; tert-Butyl 3-(2-pyrimidinyl)-1-azetidinecarboxylate; 3-(Pyrimidin-2-yl)azetidine-1-carboxylic acid tert-butyl ester; Azetidine-1-carboxylic acid, 3-(2-pyrimidinyl)-, 1,1-dimethylethyl ester; 1236861-59-8; Boc-3-(2-Pyrimidyl)azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(pyrimidin-2-yl)azetidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP (current Good Manufacturing Practice) for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.