Description

n-Boc-5-Bromo-2-Pyrimidinemethanamine is a high-purity, protected amine building block essential for advanced organic synthesis. This compound matters because it provides a versatile and reactive handle for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require functionalized pyrimidine cores.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Peptidomimetics & PROTACs: The Boc-protected amine is crucial for constructing peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs) in drug discovery.
• Material Science: Serves as a precursor for functionalized ligands and monomers used in advanced polymers and coordination chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	n-Boc-5-Bromo-2-Pyrimidinemethanamine
CAS No.	1235451-38-3
Molecular Formula	C10H14BrN3O2
Molecular Weight	288.14 g/mol
Synonyms	tert-Butyl N-[(5-bromopyrimidin-2-yl)methyl]carbamate; 5-Bromo-2-pyrimidinemethanamine, N-Boc-protected; (5-Bromo-2-pyrimidinyl)methylcarbamic acid 1,1-dimethylethyl ester; N-Boc-5-bromo-2-pyrimidinemethylamine; N-(tert-Butoxycarbonyl)-5-bromo-2-pyrimidinemethanamine; Boc-5-Br-Pym-NH2; 2-((tert-Butoxycarbonylamino)methyl)-5-bromopyrimidine
EINECS	Contact for details

Quality Control

Our n-Boc-5-Bromo-2-Pyrimidinemethanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for each lot, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.