Description

(R)-n-Acetyl-6-Fluoro-Trp-Ome is a high-purity, non-natural amino acid derivative featuring a chiral center and a fluorine substituent. This compound is a critical chiral building block for the synthesis of complex bioactive molecules, offering precise stereochemical control and enhanced metabolic stability. It is primarily needed by pharmaceutical R&D and process chemistry teams for applications in peptide mimetics, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Peptidomimetics & Drug Discovery: Used to incorporate fluorinated tryptophan analogs into peptide backbones to modulate biological activity, bioavailability, and stability.
• Proteomics & Biochemical Research: Serves as a specialized reagent for studying enzyme-substrate interactions and protein structure-function relationships.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis for creating complex molecular architectures.
• Fluorine Chemistry Libraries: A valuable component for constructing focused libraries in medicinal chemistry to explore structure-activity relationships (SAR).

Basic Information

Product Name	(R)-n-Acetyl-6-Fluoro-Trp-Ome
CAS No.	1234842-62-6
Molecular Formula	C₁₄H₁₅FN₂O₃
Molecular Weight	278.28 g/mol
Synonyms	(R)-Methyl 2-acetamido-3-(6-fluoro-1H-indol-3-yl)propanoate; (R)-N-Acetyl-6-fluoro-L-tryptophan methyl ester; Methyl (R)-2-acetamido-3-(6-fluoro-1H-indol-3-yl)propanoate; (R)-6-Fluoro-N-acetyl-L-tryptophan methyl ester; (R)-N-Ac-6-F-Trp-OMe; (R)-Ac-6-F-Trp-OMe; (R)-Ac-6-F-Trp-Me; (R)-6-Fluoro-N-acetyltryptophan methyl ester
EINECS	Contact for details

Quality Control

Our (R)-n-Acetyl-6-Fluoro-Trp-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.