Description

Tenapanor is a selective, minimally absorbed inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) with the CAS registry number 1234423-95-0. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of novel therapeutics. It is primarily required by pharmaceutical manufacturers and advanced research institutions focused on addressing significant unmet medical needs in gastroenterology and related metabolic disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of finished dosage forms for the treatment of irritable bowel syndrome with constipation (IBS-C).
• Clinical Research: Serves as a key reference standard and investigational compound in preclinical and clinical trials for gastrointestinal disorders.
• Drug Development: Utilized in formulation studies for developing tablets or other solid oral dosage forms to ensure stability and bioavailability.
• Metabolic Disorder Research: Investigated for potential applications in managing hyperphosphatemia in chronic kidney disease patients due to its mechanism of action.
• Biochemical Research: Used as a specific pharmacological tool to study NHE3 transporter function and ion absorption pathways in laboratory settings.

Basic Information

Product Name	Tenapanor
CAS No.	1234423-95-0
Molecular Formula	C44H42N6O6S2
Molecular Weight	815.0 g/mol
Synonyms	Tenapanor; AZD-1722; RDX-5791; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-4,6-dimethylphenyl methyl ester; NHE3 inhibitor AZD1722; NHE3 inhibitor RDX5791
EINECS	Contact for details

Quality Control

Our Tenapanor is manufactured under strict quality management systems, targeting high-purity standards suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic methods. A Certificate of Analysis (COA) detailing all specifications and results is provided to ensure full traceability and compliance with cGMP guidelines for API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.