Description

Istaroxime CAS NO 1234319-68-6 is a novel, dual-acting investigational drug candidate that functions as both a sodium-potassium ATPase inhibitor and a sarcoplasmic reticulum calcium ATPase activator. This unique mechanism of action makes it a compound of significant interest for the treatment of acute heart failure. It is primarily utilized by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions focused on advancing cardiovascular therapeutics.

Application

• Pharmaceutical R&D: Primary application in preclinical and clinical research for acute decompensated heart failure (ADHF).
• Mechanistic Studies: Used as a research tool to study cardiac inotropy and lusitropy via dual ionotropic mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in API synthesis.
• Formulation Development: Employed in the development of injectable formulations for clinical trial materials.
• Comparative Pharmacology: Used in studies comparing next-generation heart failure treatments against existing therapies.

Basic Information

Product Name	Istaroxime
CAS No.	1234319-68-6
Molecular Formula	C26H38N2O5
Molecular Weight	458.59 g/mol
Synonyms	PST-2744; (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione; (E,Z)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione; 5α-Androstane-6,17-dione, 3-[(2-aminoethoxy)imino]-, (3E,5α)-; UNII-0WVB6N708N
EINECS	Contact for details

Quality Control

Our Istaroxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral purity determination, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS). We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all critical quality attributes to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.