Description

(R)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for research and manufacturing organizations in the pharmaceutical and biotechnology sectors seeking to develop novel therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug molecules, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chemical entities (NCEs).
• Asymmetric Synthesis: Serves as a precursor in catalytic and stoichiometric asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Supports the development of robust, scalable synthetic routes from laboratory to pilot plant and commercial production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	(R)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate
CAS No.	1233860-28-0
Molecular Formula	C15H22FN3O2
Molecular Weight	295.36 g/mol
Synonyms	(R)-tert-Butyl 1-(2-amino-6-fluorophenyl)pyrrolidine-3-carbamate; (R)-1-(2-Amino-6-fluorophenyl)-N-(tert-butoxycarbonyl)pyrrolidin-3-amine; tert-Butyl (3R)-1-(2-amino-6-fluorophenyl)pyrrolidin-3-ylcarbamate; (R)-1-(2-Amino-6-fluorophenyl)pyrrolidin-3-yl-carbamic acid tert-butyl ester; BOC-(R)-1-(2-Amino-6-fluorophenyl)pyrrolidin-3-amine; (R)-Boc-1-(2-Amino-6-fluorophenyl)pyrrolidin-3-amine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(2-Amino-6-Fluorophenyl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.