Description

4-Ethynyl-3-Fluorobenzenamine is a high-value fluorinated aromatic amine building block featuring a reactive ethynyl group. This compound is essential for advanced organic synthesis, particularly in the construction of complex molecular architectures for pharmaceutical and materials science research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and oncology drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of advanced polymers, resins, and conductive organic materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: Utilized as a core structure for creating fluorescent dyes and molecular probes used in bioimaging and diagnostics.
• Click Chemistry: The terminal alkyne group makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer chemistry.

Basic Information

Product Name	4-Ethynyl-3-Fluorobenzenamine
CAS No.	1233501-57-9
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	3-Fluoro-4-ethynylaniline; 4-Amino-2-fluorophenylacetylene; 2-Fluoro-4-aminophenylacetylene; 4-Ethynyl-3-fluoroaniline; 3-Fluoro-4-ethynylbenzenamine; 4-(Ethynyl)-3-fluoroaniline; 2-Fluoro-4-ethynylaniline
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-3-Fluorobenzenamine is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Light yellow to brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.