Description

4-Ethynyl-3,5-Difluorobenzenamine is a high-purity, multi-functional aromatic amine building block featuring both an ethynyl group and fluorine substituents. This compound is valued for its role as a key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and advanced organic electronic materials.
• Ligand and Catalyst Development: The ethynyl and amine functionalities make it a valuable scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Fluorescent Probe and Dye Synthesis: Employed in the design and synthesis of fluorophores and molecular probes for bio-imaging and diagnostic applications.
• Academic and Industrial R&D: A versatile reagent for exploratory chemistry in medicinal chemistry, chemical biology, and process development laboratories.

Basic Information

Product Name	4-Ethynyl-3,5-Difluorobenzenamine
CAS No.	1233501-56-8
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	3,5-Difluoro-4-ethynylaniline; 4-Amino-2,6-difluorophenylacetylene; 2,6-Difluoro-4-ethynylbenzenamine; 4-Ethynyl-2,6-difluoroaniline; 4-Ethynyl-3,5-difluoroaniline; Benzenamine, 4-ethynyl-3,5-difluoro-; 3,5-Difluoro-4-ethynylphenylamine
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-3,5-Difluorobenzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.