Description

2-Bromo-3,5-Difluorobenzaldehyde is a versatile and highly functionalized aromatic aldehyde building block. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules in advanced chemical synthesis. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro and bromo groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing character.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Fluorinated Compound Libraries: A valuable starting material for generating libraries of fluorinated compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	2-Bromo-3,5-Difluorobenzaldehyde
CAS No.	1232407-50-9
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	3,5-Difluoro-2-bromobenzaldehyde; Benzaldehyde, 2-bromo-3,5-difluoro-; 2-Bromo-3,5-difluorobenzenecarboxaldehyde; 3,5-Difluoro-2-bromobenzenecarbaldehyde; 2-Bromo-3,5-difluoro benzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for prolonged use to minimize potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.