Description

Biotin-Tat (47-57) is a synthetic peptide conjugate that combines the high-affinity vitamin biotin with the cell-penetrating peptide sequence Tat (47-57). This compound is a critical tool in molecular and cellular biology for targeted delivery and labeling applications. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic sectors. The product is supplied under the CAS registry number 1231898-25-1.

Application

• Intracellular Delivery Studies: Utilized as a vehicle for transporting biotinylated cargo (e.g., drugs, probes, proteins) across cell membranes for intracellular research.
• Affinity Purification & Pull-Down Assays: Acts as a high-affinity ligand for streptavidin/avidin matrices to isolate and study protein complexes and biomolecular interactions.
• Diagnostic Probe Development: Serves as a building block for creating advanced diagnostic and imaging agents that require cell-penetrating capabilities.
• Drug Delivery System Research: Investigated as a component in novel drug delivery platforms designed to enhance the cellular uptake of therapeutic agents.
• Bioconjugation & Labeling: Used to create biotin-tagged molecules for detection, localization, and quantification in various assay formats (e.g., ELISA, flow cytometry).
• Neuroscience Research: Applied in studies requiring the delivery of compounds across the blood-brain barrier or into neuronal cells.

Basic Information

Product Name	Biotin-Tat (47-57)
CAS No.	1231898-25-1
Molecular Formula	C73H122N24O17S
Molecular Weight	1567.9 g/mol
Synonyms	Biotin-TAT (47-57); Biotin-Tat Peptide; Biotinylated HIV-1 Tat (47-57); Biotin-GRKKRRQRRRPPQ-NH2; Biotin-Tat Cell Penetrating Peptide; Biotin-Tat47-57; Biotin-Tat (GRKKRRQRRRPPQ); N-Biotinyl-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-NH2
EINECS	Contact for details

Quality Control

Our Biotin-Tat (47-57) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS (Mass Spectrometry) for identity confirmation. A Certificate of Analysis (COA) detailing the specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.