Description

3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic acid pinacol ester group. This compound is a critical building block in modern synthetic chemistry, enabling the efficient construction of complex molecules through cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, which are common motifs in drug discovery.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the research and production of active pharmaceutical ingredients (APIs), particularly for fluorinated compounds.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the difluoroaniline and boronate functionalities impart specific biological activity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and labeling strategies due to its reactive amine and boronate groups.

Basic Information

Product Name	3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.	1231892-38-8
Molecular Formula	C12H16BF2NO2
Molecular Weight	255.07 g/mol
Synonyms	4-Amino-3,5-difluorophenylboronic acid pinacol ester; 2-(4-Amino-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-difluoroaniline; B-(4-Amino-3,5-difluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.