Description

Fmoc-α-Me-D-Asp(Otbu)-Oh is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide backbone structure and stereochemistry to modulate biological activity and stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing a methylated aspartic acid residue with orthogonal side-chain protection (OtBu) under Fmoc chemistry protocols.
• Peptidomimetic Drug Discovery: For creating constrained peptide analogs with enhanced metabolic stability, bioavailability, and target selectivity for therapeutic applications.
• Bioconjugation and Probe Development: Serving as a modified amino acid component in the synthesis of labeled peptides for imaging, diagnostic assays, and studying protein-protein interactions.
• Academic and Industrial Research: Used in chemical biology to investigate enzyme specificity, receptor-ligand binding, and structure-activity relationships (SAR).
• API Intermediate Manufacturing: As a specialized intermediate in the multi-step synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-α-Me-D-Asp(Otbu)-Oh
CAS No.	1231709-26-4
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-α-methyl-D-aspartic acid β-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-D-aspartic acid 4-tert-butyl ester; Fmoc-D-α-Me-Asp(OtBu)-OH; Fmoc-α-Me-D-Asp(OtBu)-OH; N-Fmoc-α-methyl-D-aspartic acid β-t-butyl ester; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-4-(tert-butoxy)-4-oxobutanoic acid; Fmoc-D-Asp(OMe)-OtBu (common abbreviation); Fmoc-α-Me-Asp(OtBu)-OH (D-isomer)
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Asp(Otbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.