Description

Fmoc-α-Methyl-D-Leucine CAS NO 1231709-23-1 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering enhanced metabolic stability and conformational control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers specializing in peptide drugs, diagnostic agents, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly those requiring D-configuration and α-methylation for stability.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the development of peptide therapeutics targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Drug Design: Used to create peptide analogs with improved bioavailability, receptor selectivity, and resistance to enzymatic degradation.
• Bioconjugation and Labeling: Facilitates the site-specific incorporation of functional groups or labels into peptide sequences for diagnostic and imaging applications.
• Academic and Industrial Research: Essential for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR) in medicinal chemistry.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specialized peptide sequences for clients.

Basic Information

Product Name	Fmoc-α-Methyl-D-Leucine
CAS No.	1231709-23-1
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-α-Me-D-Leu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-D-leucine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpentanoic acid; Fmoc-D-α-Methylleucine; Fmoc-(α-Me)-D-Leu; N-Fmoc-α-methyl-D-leucine; D-α-Methylleucine Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-α-Methyl-D-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.