Description

4-(3-Chloro-Phenyl)-Pyrimidine-2-Thiol is a high-purity, sulfur-containing heterocyclic compound that serves as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile pyrimidine-thiol scaffold essential for developing novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new molecular entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Building block for developing new fungicides, herbicides, and plant growth regulators.
• Material Science: Used in the development of organic semiconductors, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology: Serves as a probe or linker in bioconjugation and proteomics research due to its reactive thiol group.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring functionalized pyrimidines.

Basic Information

Product Name	4-(3-Chloro-Phenyl)-Pyrimidine-2-Thiol
CAS No.	1231244-54-4
Molecular Formula	C10H7ClN2S
Molecular Weight	222.69 g/mol
Synonyms	2-Mercapto-4-(3-chlorophenyl)pyrimidine; 4-(3-Chlorophenyl)-2-pyrimidinethiol; 4-(3-Chlorophenyl)pyrimidine-2-thione; 2(1H)-Pyrimidinethione, 4-(3-chlorophenyl)-; 3-Chlorophenyl-2-thiopyrimidine; 4-(m-Chlorophenyl)-2-mercaptopyrimidine; 2-Thiol-4-(3-chlorophenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(3-Chloro-Phenyl)-Pyrimidine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.