Description

3-(Benzyloxy)-6-Bromo-2-Fluorophenol is a high-purity fluorinated phenolic intermediate with a benzyl-protecting group. This compound is valued for its unique halogenated structure, which makes it a critical building block in advanced organic synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used as a precursor for developing novel herbicides and pesticides that leverage the bioactivity of halogenated phenols.
• Material Science: Serves as a monomer or functionalization agent in the production of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of the bromo substituent, enabling further structural diversification.
• Ligand & Catalyst Development: The phenolic and ether functionalities make it a useful scaffold for designing novel chelating ligands and organocatalysts.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new synthetic pathways in process chemistry.

Basic Information

Product Name	3-(Benzyloxy)-6-Bromo-2-Fluorophenol
CAS No.	1228956-98-6
Molecular Formula	C₁₃H₁₀BrFO₂
Molecular Weight	297.12 g/mol
Synonyms	6-Bromo-2-fluoro-3-(phenylmethoxy)phenol; 2-Fluoro-6-bromo-3-benzyloxyphenol; Phenol, 3-(benzyloxy)-6-bromo-2-fluoro-; 3-Benzyloxy-6-bromo-2-fluorophenol; 2-Fluoro-3-benzyloxy-6-bromophenol; 6-Bromo-2-fluoro-3-(benzyloxy)phenol; 3-(Benzyloxy)-6-bromo-2-fluorophenol; BBFPH
EINECS	Contact for details

Quality Control

Our 3-(Benzyloxy)-6-Bromo-2-Fluorophenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.