Description

Fmoc-D-Dap(Ivdde)-Oh CAS NO 1228900-15-9 is a protected, non-proteinogenic amino acid derivative, specifically an Fmoc-protected D-diaminopropionic acid with an ivDde side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides with orthogonal protection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide-based diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of custom peptides with specific side-chain functionalities.
• Orthogonal Protection Strategy: The ivDde protecting group allows for selective deprotection in the presence of other common protecting groups like Fmoc, facilitating complex, multi-step syntheses.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting various diseases.
• Bioconjugation and Labeling: The free amino group after ivDde deprotection can be used for site-specific conjugation with fluorescent dyes, biotin, or other molecules.
• Peptide Library Construction: Essential for creating diverse peptide libraries for screening in drug discovery and biochemical assays.
• Structural Biology Studies: Incorporation into peptides to study protein-protein interactions and enzyme mechanisms.

Basic Information

Item	Detail
Product Name	Fmoc-D-Dap(Ivdde)-Oh
CAS No.	1228900-15-9
Molecular Formula	C₃₀H₃₅N₃O₇
Molecular Weight	549.62 g/mol
Synonyms	Fmoc-D-Dap(ivDde)-OH; N-α-Fmoc-N-β-(1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl)-D-diaminopropionic acid; Fmoc-D-2,3-diaminopropionic acid(ivDde)-OH; Fmoc-D-Dap(ivDde); (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]propanoic acid; Fmoc-D-2,3-diaminopropanoic acid(ivDde)-OH; Fmoc-D-Dap(Ivdde)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dap(Ivdde)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and optical rotation analysis to ensure chiral integrity and compliance with research-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.