Description

2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride is a high-purity fluorinated amine hydrochloride salt, a key building block in advanced organic synthesis. This compound matters for its role in introducing the trifluoroethylamine pharmacophore, a critical structural motif known to enhance metabolic stability, lipophilicity, and bioavailability in drug candidates. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of complex drug molecules, especially those requiring a trifluoroethylamine moiety.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the fluorine atoms contribute to improved activity and environmental persistence.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and material science applications.
• Fluorinated Building Block: A versatile reagent for introducing fluorine-containing groups into complex organic frameworks in medicinal and process chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and target engagement.

Basic Information

Product Name	2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride
CAS No.	1228879-32-0
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	1-(3-Methylphenyl)-2,2,2-trifluoroethanamine hydrochloride; α-(Trifluoromethyl)-m-tolylmethylamine hydrochloride; m-Tolyl(trifluoroethyl)amine HCl; 2,2,2-Trifluoro-1-(3-methylphenyl)ethanamine hydrochloride; 1-(3-Methylphenyl)-2,2,2-trifluoroethylamine hydrochloride; (3-Methylphenyl)(2,2,2-trifluoroethyl)amine hydrochloride; 2,2,2-Trifluoro-1-(m-tolyl)ethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent decomposition. Keep away from incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.