Description

Cyclopropanemethanamine, 1-(2-Fluorophenyl)-, Hydrochloride CAS NO 1228878-99-6 is a high-purity, fluorinated cyclopropane derivative supplied as a hydrochloride salt. This compound is a critical pharmaceutical intermediate valued for its unique structural motif, which is essential in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to the conformational rigidity imparted by the cyclopropane ring.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for new chemical entities (NCEs).
• Biochemical Research: Potential use as a probe or tool compound in biochemical assays and target validation studies.
• Custom Synthesis: A substrate for further chemical modifications, such as cross-coupling reactions or functional group transformations, to create specialized libraries.

Basic Information

Product Name	Cyclopropanemethanamine, 1-(2-Fluorophenyl)-, Hydrochloride
CAS No.	1228878-99-6
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	1-(2-Fluorophenyl)cyclopropanemethanamine Hydrochloride; (1-(2-Fluorophenyl)cyclopropyl)methanamine Hydrochloride; 2-Fluoro-α-(aminomethyl)benzenepropanenitrile Hydrochloride (related); 1-(2-Fluorobenzyl)cyclopropanamine Hydrochloride; FC-Pharmaceutical Intermediate 1228878; 2-Fluorophenyl cyclopropane methylamine HCl; α-(Aminomethyl)-2-fluorobenzenepropanenitrile Hydrochloride (related); 1-(2-Fluorophenyl)cyclopropylmethylamine Hydrochloride
EINECS	Contact for details

Quality Control

Our Cyclopropanemethanamine, 1-(2-Fluorophenyl)-, Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.