Description

3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-1-(tert-Butoxycarbonyl)Pyrrolidine-3-Carboxylic Acid (Wxc02584) is a sophisticated, dual-protected amino acid derivative designed for advanced peptide synthesis. This compound matters because it provides orthogonal protection for both the amine and carboxylic acid functionalities, enabling precise, sequential deprotection strategies in complex molecular assembly. Pharmaceutical R&D and biotechnology companies need it as a critical building block for developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of modified proline or other constrained amino acids into peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide drugs targeting GPCRs and other biological pathways.
• Constrained Peptide Design: Used to introduce conformational constraints into peptide sequences, enhancing their metabolic stability, bioavailability, and target selectivity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation and Linker Chemistry: The orthogonal protecting groups allow for selective functionalization, making it useful for creating peptide-drug conjugates or labeled probes.
• Academic and Institutional Research: A valuable reagent for studies in organic chemistry, medicinal chemistry, and chemical biology focused on peptide mimetics and protein engineering.

Basic Information

Product Name	3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-1-(tert-Butoxycarbonyl)Pyrrolidine-3-Carboxylic Acid (Wxc02584)
CAS No.	1228551-85-6
Molecular Formula	C25H28N2O6
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-3-Amino-1-Boc-pyrrolidine-3-carboxylic Acid; 1-Boc-3-(Fmoc-amino)pyrrolidine-3-carboxylic Acid; 3-[(Fmoc-amino)]-1-[(tert-butoxycarbonyl)]pyrrolidine-3-carboxylic Acid; (3S)-1-[(tert-Butoxycarbonyl)]-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pyrrolidine-3-carboxylic Acid; (R)-1-Boc-3-(Fmoc-amino)pyrrolidine-3-carboxylic Acid; Fmoc-Amino-Boc-Pyrrolidine-3-Carboxylic Acid; WXC-02584; Boc-Pyrrolidine(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our 3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-1-(tert-Butoxycarbonyl)Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.